Technology

 Many of the deadliest cancers  share a common feature: Chromosomal Instability (CIN). CIN manifests as an accumulation of structural and numerical chromosomal abnormalities in cancer cells. These changes result in chaotic genomes, and are associated with metastasis, poor prognosis and treatment resistance. 

Precision medicine approaches have improved the survival rates of many cancers. However, these improvements have been focussed on cancers without CIN. Cancers with extreme CIN have not seen significant improvements in overall survival. Therefore, there is an unmet need for treating cancers with CIN. 

   Many precision medicine approaches are currently based on the detection of small single gene mutations. However, the chaotic genomic landscape caused by CIN limits our ability to personalise treatment using single gene mutations as a target.

Instead, our precision medicine platform use CIN signatures, which are patterns of change of chromosomal copy numbers, to personalise treatment. Different types of CIN leave unique genomic footprints that can be linked to specific mutational processes. These processes are often the same across multiple different tumour types. Hence, we can use these signatures as mutation agnostic pan-cancer biomarkers for targeting defective pathways. 

  A deeper understanding of the underlying mechanisms of CIN enables new opportunities in precision medicine.  

Tailor Bio’s pan-cancer precision medicine platform unlocks new drug discovery opportunities for cancers with CIN. Additionally, it enables new patient stratification methods to predict treatment respone for targeted therapies and chemotherapy.